製品の概要

  • 製品名Anti-TLR1 antibody
    TLR1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TLR1
  • アプリケーション適用あり: WB, Flow Cytmore details
  • 種交差性
    交差種: Human
    非交差種: Mouse
  • 免疫原

    Synthetic peptide:

    LQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKV L

    conjugated to KLH, corresponding to amino acids 400-450 of Human TLR1.

  • ポジティブ・コントロール
    • Ramos

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab22057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 87 kDa.
Flow Cyt Use 2-4µg for 106 cells. ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 組織特異性Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
  • 配列類似性Belongs to the Toll-like receptor family.
    Contains 12 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 細胞内局在Cell membrane. Cytoplasmic vesicle > phagosome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD281 antibody
    • CD281 antigen antibody
    • KIAA0012 antibody
    • LPRS5 antibody
    • rsc786 antibody
    • TIL antibody
    • TIL. LPRS5 antibody
    • Tlr1 antibody
    • TLR1_HUMAN antibody
    • Toll (Drosophila) homolog antibody
    • Toll like receptor 1 antibody
    • Toll-like receptor 1 antibody
    • Toll/interleukin-1 receptor-like protein antibody
    see all

Anti-TLR1 antibody 画像

  • All lanes : Anti-TLR1 antibody (ab22057) at 2 µg/ml

    Lane 1 : Ramos whole cell lysate (ab3955)
    Lane 2 : RAW 264.7 whole cell lysate (ab7187)


    Observed band size : 87 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 190 kDa,32 kDa,60 kDa. We are unsure as to the identity of these extra bands.
  • ab22057, at 4ug/106, staining TLR1 in permeabilised Ramos cells by flow ctometric analysis (open histogram).

Anti-TLR1 antibody (ab22057) 使用論文

This product has been referenced in:
  • Yokota S  et al. Highly-purified Helicobacter pylori LPS preparations induce weak inflammatory reactions and utilize Toll-like receptor 2 complex but not Toll-like receptor 4 complex. FEMS Immunol Med Microbiol 51:140-8 (2007). Read more (PubMed: 17645528) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"