製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to TIRAP
  • 特異性
    This protein is expected to recognise isoform b only (as represented by NP_683708).
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    EGEGERDSATVSDL

    , corresponding to C terminal amino acids 221-234 of Human TIRAP

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab1349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    Peptide ELISA: Antibody detection limit dilution 1:16,000.
    WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 24 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性
      The Toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production. Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. Tissue specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain. Post-translational modification: Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Sequence similarities: Contains 1 TIR domain.
    • 細胞内局在
      Cytoplasmic
    • 参照データベース
    • 別名
      • Adapter protein wyatt antibody
      • FLJ42305 antibody
      • MAL antibody
      • MyD88 adapter like protein antibody
      • TIR domain containing adapter protein antibody
      • Toll interleukin 1 receptor (TIR) domain containing adaptor protein antibody
      • Toll interleukin 1 receptor domain containing adapter protein antibody
      • Toll like receptor adaptor protein antibody
      • Wyatt antibody
      see all

    画像

    • Anti-TIRAP antibody (ab1349) at 1 µg/ml + Human Liver lysate (35ug protein in RIPA buffer)

      Predicted band size : 24 kDa

    プロトコール

    参考文献

    ab1349 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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