Anti-TIMP3 抗体 [MM0036-7D3] (ab61316)

製品の概要

  • 製品名Anti-TIMP3 antibody [MM0036-7D3]
    TIMP3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0036-7D3] to TIMP3
  • 特異性This antibody recognizes human TIMP3. No cross reactivity to human TIMP1, 2 and 4 is noted.
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human, Pig
  • 免疫原

    Recombinant full length protein (Human)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab61316 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/200.
WB 1/100 - 1/1000. Predicted molecular weight: 24 kDa.

ターゲット情報

  • 機能Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
  • 関連疾患Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
  • 配列類似性Belongs to the protease inhibitor I35 (TIMP) family.
    Contains 1 NTR domain.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HSMRK222 antibody
    • K222 antibody
    • K222TA2 antibody
    • Metalloproteinase inhibitor 3 antibody
    • MIG 5 protein antibody
    • MIG5 protein antibody
    • Protein MIG 5 antibody
    • Protein MIG-5 antibody
    • SFD antibody
    • Sorsby fundus dystrophy pseudoinflammatory antibody
    • TIMP 3 antibody
    • TIMP metallopeptidase inhibitor 3 antibody
    • TIMP-3 antibody
    • TIMP3 antibody
    • TIMP3_HUMAN antibody
    • Tissue Inhibitor of Metalloproteinase 3 antibody
    • Tissue inhibitor of metalloproteinases 3 antibody
    • Tissue inhibitor of metalloproteinases3 antibody
    see all

Anti-TIMP3 antibody [MM0036-7D3] 画像

  • ab61316 at 1/200 dilution, staining TIMP3 in human placenta tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Anti-TIMP3 antibody [MM0036-7D3] (ab61316) 使用論文

ab61316 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step Superblock as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 90% · Temperature: 25°C
Antigen retrieval step Enzymatic
Sample Pig Tissue sections (Suprarenal abdominal aorta)
Specification Suprarenal abdominal aorta
Permeabilization No
Fixative Formaldehyde
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Miss. Leng Lai Chan

Verified customer

投稿 May 01 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"