Anti-TIMP1 抗体 [RM0136-6A34] (ab86482)
Key features and details
- Rat monoclonal [RM0136-6A34] to TIMP1
- Suitable for: IHC-Fr, WB
- Reacts with: Mouse
- Isotype: IgG2
製品の概要
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製品名
Anti-TIMP1 antibody [RM0136-6A34]
TIMP1 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [RM0136-6A34] to TIMP1 -
由来種
Rat -
アプリケーション
適用あり: IHC-Fr, WBmore details -
種交差性
交差種: Mouse -
免疫原
Recombinant full length Mouse protein
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ポジティブ・コントロール
- WB: Mouse embryonic tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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特記事項(精製)
The IgG fraction of culture supernatant was purified by protein A/G affinity chromatography and 0.2µm filtered. -
ポリ/モノ
モノクローナル -
クローン名
RM0136-6A34 -
アイソタイプ
IgG2 -
研究分野
関連製品
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Compatible Secondaries
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab86482の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-Fr |
Use at an assay dependent concentration. PubMed: 21652631
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WB |
1/500 - 1/1000. Predicted molecular weight: 23 kDa.
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特記事項 |
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IHC-Fr
Use at an assay dependent concentration. PubMed: 21652631 |
WB
1/500 - 1/1000. Predicted molecular weight: 23 kDa. |
ターゲット情報
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機能
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. -
配列類似性
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain. -
翻訳後修飾
The activity of TIMP1 is dependent on the presence of disulfide bonds. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 21857 Mouse
- SwissProt: P12032 Mouse
- Unigene: 8245 Mouse
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別名
- Clgi antibody
- Collagenase inhibitor antibody
- Collagenase inhibitor, Human antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (11)
ab86482 は 11 報の論文で使用されています。
- Klepfish M et al. LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis. Front Immunol 11:480 (2020). PubMed: 32296422
- Xia F et al. Hsa_circ_0011385 accelerates the progression of thyroid cancer by targeting miR-361-3p. Cancer Cell Int 20:49 (2020). PubMed: 32082079
- Pyka-Fosciak G et al. Effect of natalizumab treatment on metalloproteinases and their inhibitors in a mouse model of multiple sclerosis. J Physiol Pharmacol 71:N/A (2020). PubMed: 32776909
- Yan A et al. CD73 Promotes Glioblastoma Pathogenesis and Enhances Its Chemoresistance via A2B Adenosine Receptor Signaling. J Neurosci 39:4387-4402 (2019). PubMed: 30926752
- Chen H et al. Thalidomide Prevented and Ameliorated Pathogenesis of Crohn's Disease in Mice via Regulation of Inflammatory Response and Fibrosis. Front Pharmacol 10:1486 (2019). PubMed: 31920668