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RabMAb

Anti-TIMP1 抗体 [EPR1550] (ab109125)

製品の概要

  • 製品名Anti-TIMP1 antibody [EPR1550]
    TIMP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR1550] to TIMP1
  • アプリケーション適用あり: WB, IHC-Pmore details
    適用なし: Flow Cyt,ICC or IP
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to Human TIMP1 aa 50-150.

  • ポジティブ・コントロール
    • HL60+TPA, PBMC lysates; Human liver tissue; TIMP1 recombinant protein
  • 特記事項

     

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Produced using Abcam's RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5, 675, 063 and/or 7, 429, 487.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab109125 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 23 kDa.
IHC-P 1/8000.

See protocols (link: http://www.abcam.com/protocols/ihc-antigen-retrieval-protocol).

For unpurified use at 1/250 - 1/500.

  • 追加情報Is unsuitable for Flow Cyt,ICC or IP.
  • ターゲット情報

    • 機能Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
    • 配列類似性Belongs to the protease inhibitor I35 (TIMP) family.
      Contains 1 NTR domain.
    • 翻訳後修飾The activity of TIMP1 is dependent on the presence of disulfide bonds.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Clgi antibody
      • Collagenase inhibitor antibody
      • Collagenase inhibitor, Human antibody
      • EPA antibody
      • EPO antibody
      • Erythroid Potentiating Activity antibody
      • Erythroid-potentiating activity antibody
      • Fibroblast collagenase inhibitor antibody
      • FLJ90373 antibody
      • HCI antibody
      • Human Collagenase Inhibitor antibody
      • Metalloproteinase inhibitor 1 antibody
      • Metalloproteinase inhibitor 1 precursor antibody
      • OTTHUMP00000023214 antibody
      • TIMP 1 antibody
      • TIMP antibody
      • TIMP metallopeptidase inhibitor 1 antibody
      • TIMP-1 antibody
      • Timp1 antibody
      • TIMP1 protein antibody
      • TIMP1_HUMAN antibody
      • Tissue Inhibitor of Metalloproteinase 1 antibody
      • Tissue inhibitor of metalloproteinases 1 antibody
      • Tissue inhibitor of metalloproteinases antibody
      • Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor antibody
      see all

    Anti-TIMP1 antibody [EPR1550] 画像

    • ab109125, at 1/250 dilution staining TIMP1 in paraffin-embedded Human liver tissue, by Immunohistochemistry.
    • All lanes : Anti-TIMP1 antibody [EPR1550] (ab109125) at 1/1000 dilution

      Lane 1 : HL60+TPA cell lysates
      Lane 2 : PBMC cell lysates

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 23 kDa
    • Anti-TIMP1 antibody [EPR1550] (ab109125) at 1/1000 dilution + TIMP1 recombinant protein at 10 µg

      Predicted band size : 23 kDa

    Anti-TIMP1 antibody [EPR1550] (ab109125) 使用論文

    This product has been referenced in:
    • Wang C  et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep 6:34330 (2016). WB ; Human . Read more (PubMed: 27680712) »
    • Lu X  et al. Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction. Onco Targets Ther 9:4343-9 (2016). IHC . Read more (PubMed: 27486337) »

    See all 3 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab109125.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"