製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 配列
      MDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRD
    • 分子量
      139 kDa

関連製品

特性

Our Abpromise guarantee covers the use of ab113078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-Timeless antibody (ab50943)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituent: 100% dH2O

関連情報

  • 別名
    • FLJ12640
    • FLJ20714
    • hTIM
    • Protein timeless homolog
    • TIM
    • TIM_HUMAN
    • TIM1
    • Timeless
    • timeless circadian clock
    • timeless circadian clock 1
    • timeless homolog
    • TIMELESS1
    • Tof1 homolog
    see all
  • 機能
    Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
  • 組織特異性
    Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.
  • 配列類似性
    Belongs to the timeless family.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

参考文献

ab113078 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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