Yu HP et al.TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway.Sci Rep 5:9853 (2015).
WB
.
PubMed: 25928429
Wong EY et al.
TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells.
Oncol Lett 9:569-574 (2015).
PubMed: 25621025
Rajeshkumar NV et al.Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.Cancer Res 75:3355-64 (2015).
PubMed: 26113084
Zhao Y et al.Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice.Front Aging Neurosci 6:10 (2014).
WB
;
Mouse
.
PubMed: 24575038
Xie JM et al.TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy.Cancer Res 74:5127-38 (2014).
PubMed: 25085248
Patel AS et al.Autophagy in idiopathic pulmonary fibrosis.PLoS One 7:e41394 (2012).
WB
;
Mouse
.
PubMed: 22815997
Martinez-Outschoorn UE et al.Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.Cancer Biol Ther 12:924-38 (2011).
PubMed: 22041887
Ko YH et al.Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance.Cancer Biol Ther 12:1085-97 (2011).
PubMed: 22236876
Yin L et al.Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by downregulating TIGAR expression and depleting NADPH.Blood : (2011).
WB
.
PubMed: 22117045
Zhong L et al.The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1alpha.Cell 140:280-293 (2010).
WB
;
Mouse
.
PubMed: 20141841
Martinez-Outschoorn UE et al.Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NF?B activation in the tumor stromal microenvironment.Cell Cycle 9:3515-33 (2010).
ICC/IF
;
Human
.
PubMed: 20855962
Lui VW et al.An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation.Biochem Pharmacol 79:1772-80 (2010).
WB
;
Human
.
PubMed: 20219441
Favier J et al.The warburg effect is genetically determined in inherited pheochromocytomas.PLoS One 4:e7094 (2009).
IHC-P
;
Human
.
PubMed: 19763184
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"