製品の概要
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製品名Anti-TIF1 gamma antibody
TIF1 gamma 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to TIF1 gamma
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アプリケーション適用あり: IHC-Pmore details
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種交差性交差種: Mouse, Human
交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis, Platypus
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免疫原
Synthetic peptide mapping to a region within C terminal residues 1077 - 1127 of Human TIF1 gamma (NP_056990.3)
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ポジティブ･コントロール
- Human: prostate or colon adenocarcinoma. Mouse: teratoma.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab84455 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
追加情報
IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer will enhance staining.
Note: likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Note: likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
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組織特異性Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.
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パスウェイProtein modification; protein ubiquitination.
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関連疾患Defects in TRIM33 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TRIM33 is found in thyroid papillary carcinomas. Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.
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配列類似性Belongs to the TRIM/RBCC family.
Contains 2 B box-type zinc fingers.
Contains 1 bromo domain.
Contains 1 PHD-type zinc finger.
Contains 1 RING-type zinc finger. -
細胞内局在Nucleus. In discrete nuclear dots resembling nuclear bodies.
- Information by UniProt
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参照データベース
- Entrez Gene: 51592 Human
- Entrez Gene: 94093 Mouse
- Entrez Gene: 365894 Rat
- Omim: 605769 Human
- SwissProt: Q9UPN9 Human
- SwissProt: Q99PP7 Mouse
- Unigene: 26837 Human
- Unigene: 195036 Mouse
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別名
- 8030451N04Rik antibody
- AI413936 antibody
- cb1085 antibody
see all
Anti-TIF1 gamma antibody 画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TIF1 gamma antibody (ab84455)Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate adenocarcinoma using 1/250 ab84455, followed by DAB staining. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TIF1 gamma antibody (ab84455)Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse teratoma tissue using 1/250 ab84455, followed by DAB staining. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TIF1 gamma antibody (ab84455)Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human colon adenocarcinoma tissue using 1/250 ab84455, followed by DAB staining.
Anti-TIF1 gamma antibody (ab84455) 使用論文
ab84455 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"