Anti-TICAM2 抗体 (Alkaline Phosphatase) (ab26086)

製品の概要

  • 製品名
    Anti-TICAM2 antibody (Alkaline Phosphatase)
    TICAM2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TICAM2 (Alkaline Phosphatase)
  • 標識
    Alkaline Phosphatase
  • 特異性
    ab26086 recognises TICAM 2 protein.
  • アプリケーション
    適用あり: ELISA, Dot blot, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide from the unique amino-terminal end of the protein, conjugated to KLH (peptide was post-synthetically modified to achieve highest antigenicty before used for coupling to KLH using heterobifunctional cross linker).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab26086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/20000.
Dot blot 1/20000.
WB 1/500 - 1/750. Predicted molecular weight: 27 kDa.

ターゲット情報

  • 機能
    Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • 組織特異性
    Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • 配列類似性
    Contains 1 TIR domain.
  • ドメイン
    The TIR domain mediates the interaction with TRAF6.
  • 翻訳後修飾
    Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • 細胞内局在
    Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Putative NF-kappa-B-activating protein 502 antibody
    • TCAM2_HUMAN antibody
    • TICAM-2 antibody
    • TICAM2 antibody
    • TIR containing adapter molecule 2 antibody
    • TIR domain containing adaptor protein antibody
    • TIR domain-containing adapter molecule 2 antibody
    • TIRAP 3 antibody
    • TIRAP3 antibody
    • TIRAP3a short form antibody
    • TIRP antibody
    • Toll-like receptor adaptor protein 3 antibody
    • Toll/interleukin-1 receptor domain-containing protein antibody
    • TRAM antibody
    • TRIF-related adapter molecule antibody
    see all

プロトコール

参考文献

ab26086 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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