製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to TICAM2
  • アプリケーション
    適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide (Human) (C terminal).

  • ポジティブ・コントロール
    • PC3 whole cell lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度
    IgG fraction
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab17221 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 10 µg/ml.
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 24 kDa.

ターゲット情報

  • 機能
    Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • 組織特異性
    Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • 配列類似性
    Contains 1 TIR domain.
  • ドメイン
    The TIR domain mediates the interaction with TRAF6.
  • 翻訳後修飾
    Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • 細胞内局在
    Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Putative NF-kappa-B-activating protein 502 antibody
    • TCAM2_HUMAN antibody
    • TICAM-2 antibody
    • TICAM2 antibody
    • TIR containing adapter molecule 2 antibody
    • TIR domain containing adaptor protein antibody
    • TIR domain-containing adapter molecule 2 antibody
    • TIRAP 3 antibody
    • TIRAP3 antibody
    • TIRAP3a short form antibody
    • TIRP antibody
    • Toll-like receptor adaptor protein 3 antibody
    • Toll/interleukin-1 receptor domain-containing protein antibody
    • TRAM antibody
    • TRIF-related adapter molecule antibody
    see all

画像



  • Predicted band size : 24 kDa
    Western Blot of PC-3 cell lysate labeling TICAM2 with Anti-TICAM2 antibody (ab17221) at 1µg/ml.
  • Anti-TICAM2 antibody (ab17221) at 1 µg/ml + PC-3 cell lysate

    Predicted band size : 24 kDa
    Western blot using ab17221 at 1 µg/ml on PC-3 cell lysate.
  • ab17221 at 10µg/ml staining TICAM2 in Raji cells by ICC/IF 

参考文献

This product has been referenced in:
  • Endo Y  et al. Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1ß and TRIF/IRF3. PLoS One 9:e98517 (2014). WB ; Human . Read more (PubMed: 24870145) »

See 1 Publication for this product

レビューと Q&A

There are currently no Customer reviews or Questions for ab17221.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録