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機能
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
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組織特異性
Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
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配列類似性
Belongs to the TIAM family.
Contains 1 DH (DBL-homology) domain.
Contains 1 PDZ (DHR) domain.
Contains 2 PH domains.
Contains 1 RBD (Ras-binding) domain.
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ドメイン
The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure.
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翻訳後修飾
Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth.
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細胞内局在
Cytoplasm. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Localizes to the plasma membrane in neurites.
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Information by UniProt
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参照データベース
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別名
- FLJ41865 antibody
- OTTHUMP00000017472 antibody
- SIF and TIAM1 like exchange factor antibody
- SIF and TIAM1-like exchange factor antibody
- STEF antibody
- T cell lymphoma invasion and metastasis 2 antibody
- T lymphoma invasion and metastasis inducing protein 2 antibody
- T-lymphoma invasion and metastasis-inducing protein 2 antibody
- TIAM 2 antibody
- TIAM-2 antibody
- Tiam2 antibody
- TIAM2_HUMAN antibody
see all