Anti-TIAM2 抗体 (ab93839)

製品の概要

• 製品名Anti-TIAM2 antibody
  TIAM2 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to TIAM2
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Mouse, Rat
  交差が予測される動物種: Human
• 免疫原

  Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human TIAM2.

  Immunogen の所有権に関して

• ポジティブ･コントロール
  • This antibody gave a positive signal in the following tissue lysates: Mouse brain; Mouse hippocampus; Mouse cerebellum; Rat cortex; Rat olfactory bulb.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーPreservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Regulators

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
• 組織特異性Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
• 配列類似性Belongs to the TIAM family.
  Contains 1 DH (DBL-homology) domain.
  Contains 1 PDZ (DHR) domain.
  Contains 2 PH domains.
  Contains 1 RBD (Ras-binding) domain.
• ドメインThe PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure.
• 翻訳後修飾Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth.
• 細胞内局在Cytoplasm. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Localizes to the plasma membrane in neurites.

• Target information above from: UniProt accession Q8IVF5 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 26230 Human
  • Entrez Gene: 24001 Mouse
  • Entrez Gene: 100362710 Rat
  • Omim: 604709 Human
  • SwissProt: Q8IVF5 Human
  • SwissProt: Q6ZPF3 Mouse
  • Unigene: 586279 Human
  • Unigene: 137134 Mouse
• 別名
  • FLJ41865 antibody
  • OTTHUMP00000017472 antibody
  • SIF and TIAM1 like exchange factor antibody

  • SIF and TIAM1-like exchange factor antibody
  • STEF antibody
  • T cell lymphoma invasion and metastasis 2 antibody
  • T lymphoma invasion and metastasis inducing protein 2 antibody
  • T-lymphoma invasion and metastasis-inducing protein 2 antibody
  • TIAM 2 antibody
  • TIAM-2 antibody
  • Tiam2 antibody
  • TIAM2_HUMAN antibody

  see all