製品の概要

  • 製品名Anti-TIAM2 antibody
    TIAM2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to TIAM2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: DVHPEAEQQP GPESGEGQKG GEQPKLVRGH FCPIKRKANS TKRDRGTLLK AQIRHQSLDS QSENATIDLN SVLEREFSVQ SLTSVVSEEC FYETESHG, corresponding to amino acids 527-625 of Human TIAM2

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab57033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
    • 組織特異性Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
    • 配列類似性Belongs to the TIAM family.
      Contains 1 DH (DBL-homology) domain.
      Contains 1 PDZ (DHR) domain.
      Contains 2 PH domains.
      Contains 1 RBD (Ras-binding) domain.
    • ドメインThe PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure.
    • 翻訳後修飾Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth.
    • 細胞内局在Cytoplasm. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Localizes to the plasma membrane in neurites.
    • Information by UniProt
    • 参照データベース
    • 別名
      • FLJ41865 antibody
      • OTTHUMP00000017472 antibody
      • SIF and TIAM1 like exchange factor antibody
      • SIF and TIAM1-like exchange factor antibody
      • STEF antibody
      • T cell lymphoma invasion and metastasis 2 antibody
      • T lymphoma invasion and metastasis inducing protein 2 antibody
      • T-lymphoma invasion and metastasis-inducing protein 2 antibody
      • TIAM 2 antibody
      • TIAM-2 antibody
      • Tiam2 antibody
      • TIAM2_HUMAN antibody
      see all

    Anti-TIAM2 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab57033 TIAM2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-TIAM2 antibody (ab57033) 使用論文

    ab57033 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab57033.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"