製品の概要

  • 製品名Anti-Thyroid Peroxidase antibody
    Thyroid Peroxidase 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Thyroid Peroxidase
  • 特異性ab123805 is expected to recognize all reported isoforms (NP_000538.3; NP_783650.1; NP_783652.1; NP_783653.1).
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    ELRCGKHQAVGTSPQ

    , corresponding to C terminal amino acids 893-907 of Human Thyroid Peroxidase (NP_000538.3; NP_783650.1; NP_783652.1; NP_783653.1).

  • ポジティブ・コントロール
    • Human thyroid gland lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 103 kDa.

ターゲット情報

  • 機能Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
  • パスウェイHormone biosynthesis; thyroid hormone biosynthesis.
  • 関連疾患Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
    Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
  • 配列類似性Belongs to the peroxidase family. XPO subfamily.
    Contains 1 EGF-like domain.
    Contains 1 Sushi (CCP/SCR) domain.
  • 翻訳後修飾Glycosylated.
    Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
    Cleaved in its N-terminal part.
  • 細胞内局在Membrane and Cell surface.
  • Information by UniProt
  • 参照データベース
  • 別名
    • MSA antibody
    • PERT_HUMAN antibody
    • TDH2A antibody
    • Thyroid microsomal antigen antibody
    • Thyroid peroxidase antibody
    • Thyroperoxidase antibody
    • TPO antibody
    • TPX antibody
    see all

Anti-Thyroid Peroxidase antibody 画像

  • ab123805 (5µg/ml) staining of paraffin embedded Human Thyroid Gland following steamed antigen retrieval with citrate buffer pH 6 and AP-staining shows textured staining in the cytoplasm of epithelial cells.

  • Anti-Thyroid Peroxidase antibody (ab123805) at 0.1 µg/ml + Thyroid Gland lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 103 kDa

Anti-Thyroid Peroxidase antibody (ab123805) 使用論文

ab123805 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"