製品の概要

  • 製品名Anti-Thyroid Peroxidase antibody [6H7]
    Thyroid Peroxidase 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [6H7] to Thyroid Peroxidase
  • 特異性This antibody recognizes specifically human thyroid peroxidase.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein (Human).

  • 特記事項Concentration varies from lot to lot and can be provided on request.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab10246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
AP Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 103 kDa.

ターゲット情報

  • 機能Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
  • パスウェイHormone biosynthesis; thyroid hormone biosynthesis.
  • 関連疾患Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
    Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
  • 配列類似性Belongs to the peroxidase family. XPO subfamily.
    Contains 1 EGF-like domain.
    Contains 1 Sushi (CCP/SCR) domain.
  • 翻訳後修飾Glycosylated.
    Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
    Cleaved in its N-terminal part.
  • 細胞内局在Membrane and Cell surface.
  • Information by UniProt
  • 参照データベース
  • 別名
    • MSA antibody
    • PERT_HUMAN antibody
    • TDH2A antibody
    • Thyroid microsomal antigen antibody
    • Thyroid peroxidase antibody
    • Thyroperoxidase antibody
    • TPO antibody
    • TPX antibody
    see all

Anti-Thyroid Peroxidase antibody [6H7] (ab10246) 使用論文

This product has been referenced in:
  • Fortunato RS  et al. Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane. J Clin Endocrinol Metab 95:5403-11 (2010). Read more (PubMed: 20826581) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"