Anti-Thyroglobulin 抗体 [EPR3615] (ab119988)

製品の概要

  • 製品名Anti-Thyroglobulin antibody [EPR3615]
    Thyroglobulin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR3615] to Thyroglobulin
  • アプリケーション適用あり: WB, IPmore details
    適用なし: Flow Cyt,ICC or IHC-P
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to residues near the C-terminus of Human Thyroglobulin.

  • ポジティブ・コントロール
    • Human thyroid lysate.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab119988 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500000 - 1/1e+006. Detects a band of approximately 300, 294 kDa (predicted molecular weight: 305 kDa).
IP 1/50.
  • 追加情報Is unsuitable for Flow Cyt,ICC or IHC-P.
  • ターゲット情報

    • 機能Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    • 組織特異性Thyroid gland specific.
    • 関連疾患Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
      Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
    • 配列類似性Belongs to the type-B carboxylesterase/lipase family.
      Contains 11 thyroglobulin type-1 domains.
    • 翻訳後修飾Sulfated tyrosines are desulfated during iodination.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AITD 3 antibody
      • AITD3 antibody
      • hTG antibody
      • TDH3 antibody
      • Tg antibody
      • TGN antibody
      • THYG_HUMAN antibody
      • Thyroglobulin antibody
      see all

    Anti-Thyroglobulin antibody [EPR3615] 画像

    • Anti-Thyroglobulin antibody [EPR3615] (ab119988) at 1/500000 dilution + Human thyroid lysate at 10 µg

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 305 kDa

    Anti-Thyroglobulin antibody [EPR3615] (ab119988) 使用論文

    ab119988 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"