製品の概要

  • 製品名
    Anti-Thyroglobulin antibody [5F9]
    Thyroglobulin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [5F9] to Thyroglobulin
  • 特異性
    This antibody does not interfere with anti-thyroglobulin autoantibodies.
  • アプリケーション
    適用あり: ELISAmore details
  • 種交差性
    交差種: Cow, Human
  • 免疫原

    Thyroglobulin from human thyroid gland.

  • 特記事項
    Concentration varies from lot to lot and can be provided on request.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.1% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度
    Protein G purified
  • 特記事項(精製)
    Purity is tested by electrophoresis.
  • ポリ/モノ
    モノクローナル
  • クローン名
    5F9
  • ミエローマ
    Sp2/0
  • アイソタイプ
    IgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab1984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
  • 追加情報
    ELISA: Use at an assay dependent dilution.
    Can be used in an ELISA pair with ab1982 (conjugate).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    • 組織特異性
      Thyroid gland specific.
    • 関連疾患
      Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
      Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
    • 配列類似性
      Belongs to the type-B carboxylesterase/lipase family.
      Contains 11 thyroglobulin type-1 domains.
    • 翻訳後修飾
      Sulfated tyrosines are desulfated during iodination.
    • 細胞内局在
      Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AITD 3 antibody
      • AITD3 antibody
      • hTG antibody
      • TDH3 antibody
      • Tg antibody
      • TGN antibody
      • THYG_HUMAN antibody
      • Thyroglobulin antibody
      see all

    参考文献

    ab1984 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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