製品の概要

  • 製品名Anti-Thromboxane synthase antibody
    Thromboxane synthase 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Thromboxane synthase
  • 特異性This antibody is specific for Thromboxane synthase.
  • アプリケーション適用あり: WB, IHC-Fr, IHC-FoFr, ICC, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human, Pig
    交差が予測される動物種: Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    TNPDCQEKLLREVDVFKEK

    , corresponding to amino acids 359/377 of Human Thromboxane synthase

  • ポジティブ・コントロール
    • Whole cell lysate from platelets.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab39362 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Detects a band of approximately 54 kDa (predicted molecular weight: 61 kDa).Can be blocked with Human Thromboxane synthase peptide (ab72365).
IHC-Fr Use at an assay dependent concentration.
IHC-FoFr Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 組織特異性Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.
  • 関連疾患Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
    Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis.
  • 配列類似性Belongs to the cytochrome P450 family.
  • 細胞内局在Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BDPLT14 antibody
    • CYP5 antibody
    • CYP5A1 antibody
    • Cytochrome P450 5A1 antibody
    • Cytochrome P450, family 5, subfamily A, polypeptide 1 antibody
    • FLJ52771 antibody
    • GHOSAL antibody
    • Platelet cytochrome P450 subfamily V antibody
    • Tbxas1 antibody
    • THAS antibody
    • THAS_HUMAN antibody
    • Thromboxane A synthase 1 (platelet) antibody
    • Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) antibody
    • Thromboxane A synthase 1 antibody
    • Thromboxane A synthase 1 platelet cytochrome P450 subfamily V antibody
    • Thromboxane-A synthase antibody
    • TS antibody
    • TXA synthase antibody
    • TXAS antibody
    • TXS antibody
    see all

Anti-Thromboxane synthase antibody 画像

  • All lanes : Anti-Thromboxane synthase antibody (ab39362) at 1 µg/ml

    Lane 1 : Human spleen tissue lysate - total protein (ab29699)
    Lane 2 : WI38 (Human lung fibroblast cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 61 kDa
    Observed band size : 54 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 21 kDa,36 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 8 minutes

Anti-Thromboxane synthase antibody (ab39362) 使用論文

This product has been referenced in:
  • Font-Nieves M  et al. Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes. J Biol Chem 287:6454-68 (2012). WB ; Mouse . Read more (PubMed: 22219191) »
  • Chu LM  et al. Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. Am J Physiol Heart Circ Physiol 302:H479-88 (2012). WB ; Pig . Read more (PubMed: 22037194) »

See all 6 Publications for this product

Product Wall

Thank you for the additional information about your samples and protocol. I will be happy to issue a refund if you like. If you are interested, we also have another antibody which I recommend as a free replacement, ab68823:

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"