Anti-Thrombopoietin 抗体 (ab40664)
Key features and details
- Rabbit polyclonal to Thrombopoietin
- Suitable for: ICC/IF, IHC-P, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Thrombopoietin antibody
Thrombopoietin 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Thrombopoietin -
由来種
Rabbit -
特異性
Cross reactivity: Thrombopoietin Human (299-332) 100%; Thrombopoietin Human recombinant ~90% Does not cross react with Erythropoietin Human recombinant. -
アプリケーション
適用あり: ICC/IF, IHC-P, WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Chimpanzee -
免疫原
Synthetic peptide: PPTGQYTLFP LPPTLPTPVV QLHPLLPDPS APTP conjugated to KLH, corresponding to amino acids 299-332 of Human Thrombopoietin Peptide available as ab93626.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Store at +4°C short term (1-2 weeks) (add antibacterial agent). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab40664の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration. PubMed: 21149592
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 37 kDa.
With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk. |
特記事項 |
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ICC/IF
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. PubMed: 21149592 |
WB
Use at an assay dependent concentration. Predicted molecular weight: 37 kDa. With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk. |
ターゲット情報
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機能
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. -
関連疾患
Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. -
配列類似性
Belongs to the EPO/TPO family. -
ドメイン
Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 7066 Human
- Omim: 600044 Human
- SwissProt: P40225 Human
- Unigene: 1166 Human
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別名
- C mpl ligand antibody
- C-mpl ligand antibody
- Megakaryocyte colony stimulating factor antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (1)
ab40664 は 1 報の論文で使用されています。
- Hoffmann O et al. Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis. Infect Immun 79:928-36 (2011). IHC-P ; Human . PubMed: 21149592