製品の概要

  • 製品名
    Anti-Thioredoxin / TRX antibody
    Thioredoxin / TRX 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Thioredoxin / TRX
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-106 of Human Thioredoxin/ TRX

  • 特記事項

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab57675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報
    WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
      ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
    • 配列類似性
      Belongs to the thioredoxin family.
      Contains 1 thioredoxin domain.
    • 翻訳後修飾
      In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.
      In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation.
    • 細胞内局在
      Nucleus. Cytoplasm. Secreted. Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ADF antibody
      • ATL derived factor antibody
      • ATL-derived factor antibody
      • DKFZp686B1993 antibody
      • MGC61975 antibody
      • SASP antibody
      • Surface associated sulphydryl protein antibody
      • Surface-associated sulphydryl protein antibody
      • testicular tissue protein Li 199 antibody
      • THIO_HUMAN antibody
      • Thioredoxin antibody
      • thioredoxin delta 3 antibody
      • TRDX antibody
      • TRX 1 antibody
      • Trx antibody
      • TRX1 antibody
      • TXN antibody
      • TXN delta 3 antibody
      • TXN protein antibody
      • zgc:92903 antibody
      see all

    画像



    • Predicted band size : 12 kDa
      Thioredoxin / TRX antibody (ab57675) at 1ug/lane + HeLa cell lysate at 25ug/lane.

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    参考文献

    ab57675 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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