製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to Themis
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Synthetic peptide:

    C-EERTINLPKSLKSH

    , corresponding to C terminal amino acids 577-590 of Mouse Themis (NP_848781.1).

  • ポジティブ・コントロール
    • Mouse spleen

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab101038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 3 µg/ml. Predicted molecular weight: 73 kDa.

ターゲット情報

  • 機能
    Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
  • 配列類似性
    Belongs to the themis family.
  • 翻訳後修飾
    Phosphorylated on Tyr residues quickly after TCR stimulation.
  • 細胞内局在
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C6orf190 antibody
    • C6orf207 antibody
    • MGC163388 antibody
    • Protein THEMIS antibody
    • SIGNALING PHOSPHOPROTEIN SPECIFIC FOR T CELLS antibody
    • SPOT antibody
    • THEMIS antibody
    • THMS1_HUMAN antibody
    • Thymocyte expressed molecule involved in selection antibody
    • Thymocyte selection associated antibody
    • Thymocyte selection pathway associated antibody
    • Thymocyte-expressed molecule involved in selection antibody
    • TSEPA antibody
    see all

画像

  • Anti-Themis antibody (ab101038) at 0.3 µg/ml + Mouse spleen lysate (in RIPA buffer) at 35 µg

    Predicted band size : 73 kDa

プロトコール

参考文献

This product has been referenced in:
  • Paster W  et al. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol 190:3749-56 (2013). Mouse . Read more (PubMed: 23460737) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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