製品の概要

  • 製品名Anti-THAP1 antibody
    THAP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to THAP1
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length Human THAP1 protein (NP_060575.1)

  • ポジティブ・コントロール
    • Jurkat cell lysate, transfected 293T cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab118368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 25 kDa.
IP Use at an assay dependent dilution.

ターゲット情報

  • 機能DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
  • 関連疾患Defects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
  • 配列類似性Belongs to the THAP1 family.
    Contains 1 THAP-type zinc finger.
  • 細胞内局在Nucleus > nucleoplasm. Nucleus > PML body.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 4833431A01Rik antibody
    • FLJ10477 antibody
    • MGC33014 antibody
    • Nuclear proapoptotic factor antibody
    • THAP 1 antibody
    • THAP domain containing apoptosis associated protein 1 antibody
    • THAP domain containing protein 1 antibody
    • THAP domain protein 1 antibody
    • THAP domain-containing protein 1 antibody
    • Thap1 antibody
    • THAP1_HUMAN antibody
    see all

Anti-THAP1 antibody 画像

  • Anti-THAP1 antibody (ab118368) at 1/1000 dilution + Jurkat cell lystate at 50 µg

    Predicted band size : 25 kDa
  • All lanes : Anti-THAP1 antibody (ab118368) at 1/1000 dilution

    Lane 1 : THAP1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 25 kDa
  • Immunoprecipitation of THAP1 transfected lysate using ab118368 and Protein A Magnetic Bead. Detected using another antibody to THAP1.

Anti-THAP1 antibody (ab118368) 使用論文

ab118368 has not yet been referenced specifically in any publications.

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