製品の概要

  • 製品名Anti-TGM1 antibody
    TGM1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TGM1
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human, Monkey
  • 免疫原

    Recombinant full length protein corresponding to Human TGM1. Recombinant full length protein expressed in insect cells (Human).
    Database link: P22735

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab22364 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
WB
  • 追加情報IHC-P: Use at an assay dependent dilution. This antibody has been tested with fluorescent detection.
    WB: 1/1000. Detects a band of approximately 90 kDa (predicted molecular weight: 90 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.
    • 関連疾患Defects in TGM1 are the cause of ichthyosis lamellar type 1 (LI1) [MIM:242300]. LI is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. It is one the most severe forms of ichthyoses apparent at birth and persisting throughout life. LI patients are born encased in a tight, shiny, translucent covering called collodion membrane. Over the first weeks of life, the collodion membrane is gradually replaced by generalized large, dark brown, plate-like scales with minimal to no erythroderma. Tautness of facial skin commonly results in ectropion, eclabium and scarring alopecia of the scalp. Common complications are severe heat intolerance and recurrent ear infections.
      Defects in TGM1 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
      Defects in TGM1 are the cause of ichthyosis congenital autosomal recessive TGM1-related (ARCI-TGM1) [MIM:242300]. A disorder of keratinization with abnormal differentiation and desquamation of the epidermis resulting in two major clinical entities. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
    • 配列類似性Belongs to the transglutaminase superfamily. Transglutaminase family.
    • 翻訳後修飾The membrane anchorage region possesses a cluster of five cysteines within which fatty acid(s) may become thioester-linked. It is subject to phorbol ester-stimulated phosphorylation and is hypersensitive to proteolysis, which releases the enzyme in a soluble form.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ARCI1 antibody
      • Epidermal TGase antibody
      • ICR2 antibody
      • KTG antibody
      • LI antibody
      • LI1 antibody
      • Protein glutamine gamma glutamyltransferase K antibody
      • Protein-glutamine gamma-glutamyltransferase K antibody
      • TG(K) antibody
      • TGase 1 antibody
      • TGASE antibody
      • TGase K antibody
      • TGase-1 antibody
      • TGK antibody
      • TGM1 antibody
      • TGM1_HUMAN antibody
      • Transglutaminase 1 (K polypeptide epidermal type I, protein glutamine gamma glutamyltransferase) antibody
      • Transglutaminase 1 antibody
      • Transglutaminase K antibody
      • Transglutaminase, keratinocyte antibody
      • Transglutaminase-1 antibody
      see all

    Anti-TGM1 antibody 画像



    • Predicted band size : 90 kDa

      Immunodetection of recombinant human tissue transglutaminase protein with polyclonal antiserum (lane 1)

      Immunodetection of recombinant human tissue transglutaminase protein with polyclonal antiserum (lane 1)

    Anti-TGM1 antibody (ab22364) 使用論文

    ab22364 has not yet been referenced specifically in any publications.

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    Thank you for your enquiry. I apologize for the delay in obtaining the information for you. This antibody has been tested using commericially available monkey oesophagus sections. The antibody has not yet been tested on cultured cells to our knowl...

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