製品の概要

  • 製品名Anti-TGF beta antibody
    TGF beta 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TGF beta
  • アプリケーション適用あり: Indirect ELISA, Neutralising, WBmore details
  • 種交差性
    交差種: Human, Pig
    交差が予測される動物種: Amphibians
  • 免疫原

    Recombinant full length proteins (Human, Pig, and Amphibian). A mixture of purified recombinant, human TGF-beta1, porcine TGF-beta 1.2, porcine TGF-beta 2 and recombinant, amphibian TGF-beta5

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab50716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Indirect ELISA Use a concentration of 1 µg/ml.
Neutralising Use at an assay dependent dilution. The ND50 of the antibody is defined as the concentration of antibody resulting in a one-half maximal inhibition of bioactivity of recombinant, human TGF-b1 when the cytokine is present at a concentration just high enough to elicit a maximum response.
WB Use a concentration of 2 µg/ml. Predicted molecular weight: 44 kDa.

ターゲット情報

  • 機能Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
  • 組織特異性Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
  • 関連疾患Defects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
  • 配列類似性Belongs to the TGF-beta family.
  • 翻訳後修飾Glycosylated.
    The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ARVD antibody
    • BSC 1 cell growth inhibitor antibody
    • CED antibody
    • Cetermin antibody
    • DPD1 antibody
    • G TSF antibody
    • Glioblastoma derived T cell suppressor factor antibody
    • LAP antibody
    • Latency-associated peptide antibody
    • Polyergin antibody
    • TGF beta 1 protein antibody
    • TGF beta 3 antibody
    • TGF beta1 antibody
    • TGF beta2 antibody
    • TGF beta3 antibody
    • TGF-beta-1 antibody
    • TGFB antibody
    • tgfb1 antibody
    • TGFB1_HUMAN antibody
    • TGFB2 antibody
    • TGFB3 antibody
    • TGFbeta antibody
    • Transforming growth factor antibody
    • Transforming growth factor beta 1 antibody
    • Transforming growth factor beta 2 antibody
    • Transforming growth factor beta 3 antibody
    see all

Anti-TGF beta antibody (ab50716) 使用論文

ab50716 has not yet been referenced specifically in any publications.

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Thank you for contacting us with your question and for your patience while I have been in touch with the lab about your enquiry.

I apologize for the confusion regarding the "alternative names" for our TGF-B antibodies. We would not ...

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Thank you for your enquiry. As you can see on the datasheet of ab50716, this is a neutralising antibody and so is definitely binding to the active form of TGF in ELISA. Unfortunately we have no definite information availanle regarding binding of the an...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"