Anti-TGF beta 1 + 2 抗体 [EPR5443] (ab124894)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR5443] to TGF beta 1 + 2
- Suitable for: WB
- Reacts with: Mouse, Human
Related conjugates and formulations
製品の概要
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製品名
Anti-TGF beta 1 + 2 antibody [EPR5443]
TGF beta 1 + 2 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR5443] to TGF beta 1 + 2 -
由来種
Rabbit -
特異性
ab124894 recognises TGF beta 1 and 2. -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF,IHC-P or IP -
種交差性
交差種: Mouse, Human
非交差種: Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ・コントロール
- A549 lysate, K562 lysate and L929 lysate.
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解離定数(KD 値)
KD = 8.64 x 10 -11 M Learn more about KD -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR5443 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab124894の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 44, 48 kDa.
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特記事項 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 44, 48 kDa. |
ターゲット情報
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関連性
Function: TGF beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. The inactive form consists of a TGFB1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT. Interacts with ASPN. Function: TGF beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Tissue specificity: TGF beta 1 is highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage. Similarity: Both belong to the TGF-beta family. -
細胞内局在
Secreted -
参照データベース
- Entrez Gene: 7040 Human
- Entrez Gene: 7042 Human
- Entrez Gene: 21803 Mouse
- Entrez Gene: 21808 Mouse
- Omim: 190180 Human
- Omim: 190220 Human
- SwissProt: P01137 Human
- SwissProt: P61812 Human
see all -
別名
- TGF-beta-1 antibody
- TGF-beta-2 antibody
- Transforming growth factor Beta 1 antibody
- Transforming growth factor Beta 2 antibody
画像
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All lanes : Anti-TGF beta 1 + 2 antibody [EPR5443] (ab124894) at 1/1000 dilution
Lane 1 : A549 cell lysate
Lane 2 : K562 lysate
Lane 3 : L929 lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 44, 48 kDa -
All lanes : Anti-TGF beta 1 + 2 antibody [EPR5443] (ab124894) at 1/1000 dilution
Lane 1 : TGF beta 2 recombinant protein
Lane 2 : TGF beta 1 recombinant protein
Lysates/proteins at 10 µg per lane.
Predicted band size: 44, 48 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab124894 は 1 報の論文で使用されています。
- Huang PS et al. The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma. Int J Mol Sci 19:N/A (2018). WB . PubMed: 29758012