製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to TFEC
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide: TLDHQIINPTLK, corresponding to N terminal amino acids 2-13 of Human TFEC.

  • ポジティブ・コントロール
    • Human Testis lysate
  • 特記事項
    Principal Names - TFEC; transcription factor EC; TCFEC; TFECL Official Gene Symbol - TFEC GenBank Accession Number – NP_036384 LocusLink ID - 22797 (human) Gene Ontology terms - transcription co-repressor; transcription co-activator; transcription factor; nucleus

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2653 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/0.5 - 1/2. Detects a band of approximately 40-45 kDa (predicted molecular weight: 40 kDa).Can be blocked with Human TFEC peptide (ab22928).

ターゲット情報

  • 機能
    Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.
  • 組織特異性
    Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon.
  • 配列類似性
    Belongs to the MiT/TFE family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bHLHe34 antibody
    • Class E basic helix-loop-helix protein 34 antibody
    • hTFEC-L antibody
    • TCFEC antibody
    • TFE-C antibody
    • Tfec antibody
    • TFEC protein antibody
    • TFEC_HUMAN antibody
    • TFECL antibody
    • Transcription factor EC antibody
    • Transcription factor EC-like antibody
    see all

画像



  • Predicted band size : 40 kDa


    ab2653 staining (1µg/ml) of Human Testis lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

プロトコール

参考文献

ab2653 has not yet been referenced specifically in any publications.

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