製品の概要

  • 製品名Anti-TFB2M antibody
    TFB2M 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to TFB2M
  • アプリケーション適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Synthetic peptide:

    CAYKWLYDETLEDR

    , corresponding to C terminal amino acids 383-396 of Human TFB2M.

  • 特記事項GenBank Accession Number - NP_071761

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab13676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent dilution. PubMed: 21113058
WB Use at an assay dependent dilution. Can be blocked with Human TFB2M peptide (ab23228). Preliminary experiments gave an approx 40kDa band in Human Brain lysate at 0.3 ug/ml. Please note that currently we cannot find an explanation in the literature for the band we observe given the predicted size of approx. 46kDda according to NP_071761

ターゲット情報

  • 機能S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
  • 組織特異性Ubiquitously expressed.
  • 配列類似性Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
  • 細胞内局在Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • N''-adenosyl(rRNA) dimethyltransferase 2 antibody
    • S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2 antibody
    • Dimethyladenosine transferase 2 antibody
    • dimethyladenosine transferase 2 mitochondrial antibody
    • FLJ22661 antibody
    • FLJ23182 antibody
    • h mtTFB antibody
    • h mtTFB2 antibody
    • h-mtTFB antibody
    • h-mtTFB2 antibody
    • HCV NS5A transactivated protein 5 antibody
    • HCV NS5A-transactivated protein 5 antibody
    • hepatitis C virus NS5A transactivated protein 5 antibody
    • Hepatitis C virus NS5A-transactivated protein 5 antibody
    • Hkp1 antibody
    • hTFB2M antibody
    • Mitochondrial 12S rRNA dimethylase 2 antibody
    • mitochondrial antibody
    • Mitochondrial dimethyladenosine transferase 2 antibody
    • Mitochondrial transcription factor B2 antibody
    • mtTFB antibody
    • mtTFB2 antibody
    • NS5ATP5 antibody
    • S-adenosylmethionine-6-N'' antibody
    • TFB2M antibody
    • TFB2M_HUMAN antibody
    • Transcription Factor B2 antibody
    • Transcription factor B2 mitochondrial antibody
    see all

Anti-TFB2M antibody (ab13676) 使用論文

This product has been referenced in:
  • Watanabe A  et al. Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription. Cardiovasc Res 90:57-67 (2011). ICC/IF ; Rat . Read more (PubMed: 21113058) »
  • Minczuk M  et al. TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res 39:4284-4299 (2011). WB ; Human . Read more (PubMed: 21278163) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"