製品の概要

  • 製品名
    Tenovin-1
  • 製品の詳細
    p53 Activator
  • 生理活性の詳細
    p53 Activator. Protects p53 from MDM2 mediated degradation through SirT1 inhibition. Inhibits downstream histone acetylation, activates p21CIP/WAF1. Potent antiproliferative effects in vitro.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Lain S  et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13:454-63 (2008). Read more (PubMed: 18455128) »

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