製品の概要

  • 製品名Anti-TEM8 antibody
    TEM8 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to TEM8
  • 特異性This antibody is expected to recognise variant 1 only.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide: RAPPPSRPPPRPSV, corresponding to C terminal amino acids 551-564 of Human TEM8.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab15724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 65 kDa.Can be blocked with Human TEM8 peptide (ab23274).

ターゲット情報

  • 機能Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
  • 組織特異性Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • 関連疾患Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • 配列類似性Belongs to the ATR family.
    Contains 1 VWFA domain.
  • ドメインBinding to PA occurs through the VWA domain.
  • 細胞内局在Cell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Anthrax toxin receptor 1 antibody
    • ANTR1_HUMAN antibody
    • Antxr1 antibody
    • ATR antibody
    • Tumor endothelial marker 8 antibody
    see all

Anti-TEM8 antibody 画像



  • Predicted band size : 65 kDa


    Western blot with Goat polyclonal to TEM8 (ab15724) at 0.3ug/ml. Human PBMC lysate (RIPA buffer, 35 ug total protein per lane). Primary ab incubated for 1 hour and detected by chemiluminescence.

Anti-TEM8 antibody (ab15724) 使用論文

ab15724 has not yet been referenced specifically in any publications.

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