Anti-TELO2 抗体 (ab122722)
Key features and details
- Rabbit polyclonal to TELO2
- Suitable for: IHC-P, WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-TELO2 antibody -
製品の詳細
Rabbit polyclonal to TELO2 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, WB, ICC/IFmore details -
種交差性
交差種: Human -
免疫原
Recombinant Protein Epitope Signature Tag antigen, corresponding to amino acids 361 - 462 of Human TELO2 (Q9Y4R8).
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ポジティブ・コントロール
- Human urinary bladder tissue
RT-4, U-251 MG and Human tonsil lysate
Human cell line U-251 MG
- Human urinary bladder tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab122722の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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WB |
Use a concentration of 0.04 - 0.4 µg/ml.
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ICC/IF |
Use a concentration of 0.25 - 2 µg/ml.
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特記事項 |
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IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
Use a concentration of 0.04 - 0.4 µg/ml. |
ICC/IF
Use a concentration of 0.25 - 2 µg/ml. |
ターゲット情報
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機能
May be involved in telomere length regulation. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. -
配列類似性
Belongs to the TEL2 family. -
細胞内局在
Cytoplasm. Membrane. Nucleus. Chromosome > telomere. - Information by UniProt
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参照データベース
- Entrez Gene: 9894 Human
- Omim: 611140 Human
- SwissProt: Q9Y4R8 Human
- Unigene: 271044 Human
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別名
- CLK2 antibody
- hCLK2 antibody
- KIAA0683 antibody
see all
画像
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All lanes : Anti-TELO2 antibody (ab122722) at 1/250 dilution
Lane 1 : RT-4
Lane 2 : U-251 MG
Lane 3 : Human plasma
Lane 4 : Human liver lysate
Lane 5 : Human tonsil lysate -
ab122722, at 1/50 dilution, staining TELO2 in paraffin-embedded Human urinary bladder tissue by Immunohistochemistry.
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ab122722, at 4 ug/ml, staining TELO2 in Human cell line U-251 MG by Immunoflourosence.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab122722 は 3 報の論文で使用されています。
- Guo Z et al. TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2. Oncol Rep 45:523-534 (2021). PubMed: 33416177
- Conde-Rubio MDC et al. The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases. Cell Death Discov 7:164 (2021). PubMed: 34226511
- Feng SW et al. Overexpression of TELO2 decreases survival in human high-grade gliomas. Oncotarget 7:46056-46066 (2016). WB, IHC . PubMed: 27329594