製品の概要

  • 製品名
    Telmisartan
  • 製品の詳細
    Selective angiotensin II (AT1) antagonist
  • 生理活性の詳細
    Selective AT1 receptor antagonist (Ki = 3.7 nM) . Partial PPAR-γ agonist.
  • 精製度
    > 99%

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab120831 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.

画像

  • ab8934 staining PPARα in serum starved HepG2 cells treated with telmisartan (ab120831), by ICC/IF. Increase in PPARα expression correlates with increased concentration of telmisartan, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120831 (telmisartan) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab8934 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

参考文献

This product has been referenced in:
  • Kusunoki H  et al. Telmisartan exerts renoprotective actions via peroxisome proliferator-activated receptor-?/hepatocyte growth factor pathway independent of angiotensin II type 1 receptor blockade. Hypertension 59:308-16 (2012). Read more (PubMed: 22252391) »
  • Nakagami H & Morishita R Obesity and gastrointestinal hormones-dual effect of angiotensin II receptor blockade and a partial agonist of PPAR-?. Curr Vasc Pharmacol 9:162-6 (2011). Read more (PubMed: 21143167) »
  • Wienen W  et al. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br J Pharmacol 110:245-52 (1993). Read more (PubMed: 8220885) »

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