製品の概要

  • 製品名Anti-Telethonin antibody
    Telethonin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Telethonin
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence: CEVSEENCER REAFWAEWKD LTLSTRPEEG CSLHEEDTQR HETYHQQGQC QVLVQRSPWL MMRMGILGRG LPEYQ, corresponding to internal sequence amino acids 8-82 of Human Telethonin.

  • ポジティブ・コントロール
    • Human heart muscle tissue; Telethonin transfected HEK293T cells.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーpH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab121868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

ターゲット情報

  • 機能Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
  • 組織特異性Heart and skeletal muscle.
  • 関連疾患Defects in TCAP are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TCAP are a cause of limb-girdle muscular dystrophy type 2G (LGMD2G) [MIM:601954]. LGMD2G is an autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle biopsy, and absence of telethonin. Cardiac muscle is involved in a subset of patients.
    Defects in TCAP are the cause of cardiomyopathy dilated type 1N (CMD1N) [MIM:607487]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 細胞内局在Cytoplasm > myofibril > sarcomere.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 19 kDa sarcomeric protein antibody
    • CMD1N antibody
    • CMH25 antibody
    • LGMD2G antibody
    • Limb girdle muscular dystrophy 2G (autosomal recessive) antibody
    • T-cap antibody
    • Tcap antibody
    • TELE antibody
    • Telethonin antibody
    • TELT_HUMAN antibody
    • Titin cap protein antibody
    • Titin-cap antibody
    see all

Anti-Telethonin antibody 画像

  • ab121868, at 1/45 dilution, staining Telethonin in paraffin-embedded Human heart muscle tissue by Immunohistochemistry.
  • All lanes : Anti-Telethonin antibody (ab121868) at 1/250 dilution

    Lane 1 : Vector only transfected HEK293T lysate
    Lane 2 : Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells

    Developed using the ECL technique
  • Immunohistochemical staining of Human heart muscle shows distinct cytoplasmic positivity using ab121868

Anti-Telethonin antibody (ab121868) 使用論文

ab121868 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"