製品の概要

  • 製品名Anti-TECTA antibody
  • 製品の詳細
    Mouse monoclonal to TECTA
  • アプリケーション適用あり: WB, ELISA, Sandwich ELISAmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Human
  • 免疫原

    Recombinant fragment corresponding to amino acids 1981-2081 of Human TECTA (NP_005413), with proprietary tag. Mol wt 37.11 kDa inclusive of tag.

  • ポジティブ・コントロール
    • Recombinant protein

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーpH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab118086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 240 kDa.
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use at an assay dependent concentration.

ターゲット情報

  • 機能One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
  • 関連疾患Defects in TECTA are the cause of deafness autosomal dominant type 12 (DFNA12) [MIM:601543]; also known as DFNA8. DFNA12 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in TECTA are the cause of deafness autosomal recessive type 21 (DFNB21) [MIM:603629].
  • 配列類似性Contains 1 NIDO domain.
    Contains 3 TIL (trypsin inhibitory-like) domains.
    Contains 1 VWFC domain.
    Contains 4 VWFD domains.
    Contains 1 ZP domain.
  • ドメインZona pellucida domain may enable to form filaments.
  • 翻訳後修飾The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.
  • 細胞内局在Cell membrane. Secreted > extracellular space > extracellular matrix. Found in the non-collagenous matrix of the tectorial membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha-tectorin antibody
    • DFNA12 antibody
    • DFNA8 antibody
    • DFNB21 antibody
    • OTTHUMP00000195078 antibody
    • TECTA antibody
    • TECTA_HUMAN antibody
    see all

Anti-TECTA antibody 画像

  • Anti-TECTA antibody (ab118086) at 1 µg/ml + Recombinant Protein at 0.1 µg
    Developed using the ECL technique

    Predicted band size : 240 kDa
  • Detection limit for recombinant proprietary tagged TECTA is 0.3 ng/ml as a capture antibody.

Anti-TECTA antibody (ab118086) 使用論文

ab118086 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"