製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58310 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 48 kDa.
ChIP Use at an assay dependent concentration. PubMed: 22529382
CHIPseq Use at an assay dependent concentration. PubMed: 22529382
ICC/IF Use at an assay dependent concentration. PubMed: 22529382

ターゲット情報

  • 機能Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
  • 組織特異性Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
  • 配列類似性Contains 1 TEA DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EFTR 2 antibody
    • EFTR2 antibody
    • hRTEF 1B antibody
    • hRTEF1B antibody
    • MGC9014 antibody
    • OTTHUMP00000238119 antibody
    • OTTHUMP00000238122 antibody
    • OTTHUMP00000238124 antibody
    • Related to TEF 1 antibody
    • Related to TEF1 antibody
    • Related transcription enhancer factor 1B antibody
    • RTEF1 antibody
    • TCF13L1 antibody
    • TEA domain family member 4 antibody
    • TEAD 4 antibody
    • TEAD-4 antibody
    • TEAD4 antibody
    • TEAD4_HUMAN antibody
    • TEF 3 antibody
    • TEF3 antibody
    • TEFR 1 antibody
    • TEFR1 antibody
    • Transcription factor 13 (SV40 transcriptional enhancer factor) like 1 antibody
    • Transcription factor 13 like 1 antibody
    • Transcription factor 13-like 1 antibody
    • Transcription factor RTEF 1 antibody
    • Transcription factor RTEF-1 antibody
    • Transcription factor RTEF1 antibody
    • Transcriptional enhancer factor 1 related antibody
    • Transcriptional enhancer factor 3 antibody
    • Transcriptional enhancer factor TEF 3 antibody
    • Transcriptional enhancer factor TEF-3 antibody
    • Transcriptional enhancer factor TEF3 antibody
    see all

Anti-TEAD4 antibody - ChIP Grade 画像



  • Predicted band size : 48 kDa
    TEAD4 antibody (ab58310) at 1ug/lane + HeLa cell lysate at 25ug/lane.

Anti-TEAD4 antibody - ChIP Grade (ab58310) 使用論文

This product has been referenced in:
  • Qi Y  et al. A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation. Nat Commun 7:ncomms11840 (2016). WB ; Human . Read more (PubMed: 27291620) »
  • O'Shaughnessy-Kirwan A  et al. Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification. Development 142:2586-97 (2015). ICC/IF ; Mouse . Read more (PubMed: 26116663) »

See all 7 Publications for this product

Product Wall

Application Immunoprecipitation
Immuno-precipitation step Other - Dynabeads Protein A
Sample Human Cell lysate - whole cell (BT16 (Brain), G401 (Nephrons), A204 (Liver))
Specification BT16 (Brain), G401 (Nephrons), A204 (Liver)
Total protein in input 200 µg
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投稿 Nov 01 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"