製品の概要

  • 製品名Anti-TDP1 antibody
    TDP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TDP1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between residues 1 and 50 of human TDP1 (NP_001008744.1)

  • ポジティブ・コントロール
    • Human Anaplastic Thyroid Carcinoma, Breast Carcinoma, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma and Stomach Adenocarcinoma tissues.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab84747 was affinity purified using an epitope specific to TDP1 immobilized on solid support.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
    • 組織特異性Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus.
    • 関連疾患Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy
    • 配列類似性Belongs to the tyrosyl-DNA phosphodiesterase family.
    • 翻訳後修飾Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.
    • 細胞内局在Nucleus. Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AI838772 antibody
      • AW493413 antibody
      • FLJ11090 antibody
      • MGC104252 antibody
      • MGC112732 antibody
      • RP24-311F12.2 antibody
      • SCAN1 antibody
      • TDP1 antibody
      • TYDP antibody
      • TYDP1_HUMAN antibody
      • Tyr-DNA phosphodiesterase 1 antibody
      • Tyrosyl-DNA phosphodiesterase 1 antibody
      see all

    Anti-TDP1 antibody 画像

    • ab84747 at 1/250 dilution staining TDP1 in human ovarian tumor by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84747 at 1/250 dilution staining TDP1 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    Anti-TDP1 antibody (ab84747) 使用論文

    ab84747 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84747.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"