Anti-TCF3 / E2A 抗体 (ab54462)

製品の概要

• 製品名Anti-TCF3 / E2A antibody
  TCF3 / E2A 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to TCF3 / E2A
• 特異性This antibody recognizes the ~75 kDa E47 protein.
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Chicken
• 免疫原

  Synthetic peptide:

  STDEVLSLEEKDLRD

  , corresponding to amino acids 517-531 of Human TCF3/ E2A
  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • Raji cell nuclear extracts.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot. Avoid freeze / thaw cycle.
• バッファーPreservative: 0.01% Thimerosal (merthiolate), <0.1% sodium azide
  Constituents: 0.2% Gelatin, PBS
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HLH / Leucine Zipper
  • HLH

  • Stem Cells
  • Signaling Pathways
  • Wnt
  • Nuclear

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Raji whole cell lysate (ab30124)

アプリケーション

ターゲット情報

• 機能Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
• 関連疾患Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1; Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.
• 配列類似性Contains 1 basic helix-loop-helix (bHLH) domain.
• ドメインthe 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
• 翻訳後修飾Phosphorylated following NGF stimulation.
• 細胞内局在Nucleus.

• Target information above from: UniProt accession P15923 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 6929 Human
  • Entrez Gene: 21423 Mouse
  • Entrez Gene: 171046 Rat
  • Omim: 147141 Human
  • SwissProt: P15923 Human
  • SwissProt: P15806 Mouse
  • SwissProt: P21677 Rat
  • Unigene: 371282 Human

  • Unigene: 3406 Mouse
  • Unigene: 10290 Rat

  see all
• 別名
  • AGM8 antibody
  • bHLHb21 antibody
  • Class B basic helix-loop-helix protein 21 antibody

  • E12 antibody
  • E2A antibody
  • E2A immunoglobulin enhancer binding factors E12/E47 antibody
  • E47 antibody
  • Helix loop helix protein HE47 antibody
  • Immunoglobulin enhancer-binding factor E12/E47 antibody
  • Immunoglobulin transcription factor 1 antibody
  • ITF1 antibody
  • Kappa-E2-binding factor antibody
  • MGC129647 antibody
  • MGC129648 antibody
  • Negative vitamin D response element binding protein antibody
  • NOL1-TCF3 fusion antibody
  • TCF-3 antibody
  • Tcf3 antibody
  • TFE2_HUMAN antibody
  • transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) antibody
  • Transcription factor 3 antibody
  • transcription factor 3 variant 3 antibody
  • Transcription factor E2-alpha antibody
  • Transcription factor ITF-1 antibody
  • VDIR antibody
  • VDR interacting repressor antibody
  • vitamin D receptor-interacting repressor antibody

  see all