製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to TCCR
  • アプリケーション
    適用あり: ICC/IF, IHC-P, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide:

    SGYEKHFLPTPEELG

    , corresponding to amino acids 611-625 of Human TCCR.

  • ポジティブ・コントロール
    • Human spleen tissue lysate.
  • 特記事項
    Stable for one year.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab5996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 70 kDa.Can be blocked with Human TCCR peptide (ab39872).

ターゲット情報

  • 機能
    Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
  • 組織特異性
    Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.
  • 配列類似性
    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 3 fibronectin type-III domains.
  • ドメイン
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Class I cytokine receptor antibody
    • CRL1 antibody
    • Cytokine receptor-like 1 antibody
    • I27RA_HUMAN antibody
    • IL-27 receptor subunit alpha antibody
    • IL-27R subunit alpha antibody
    • IL-27R-alpha antibody
    • IL-27RA antibody
    • IL27R alpha antibody
    • IL27R antibody
    • Il27ra antibody
    • Interleukin 27 receptor alpha chain precursor antibody
    • Interleukin 27 receptor antibody
    • Interleukin-27 receptor subunit alpha antibody
    • Protein CRL1 antibody
    • T cell cytokine receptor type 1 antibody
    • TCCR antibody
    • Type 1 T cell cytokine receptor antibody
    • Type I T-cell cytokine receptor antibody
    • WSX-1 antibody
    • WSX1 antibody
    • ZcytoR1 antibody
    see all

画像

  • Anti-TCCR antibody (ab5996) at 1 µg/ml + Human spleen tissue lysate
  • ab5996 at 5µg/ml staining TCCR in human spleen tissue by IHC

  • Immunofluorescence of TCCR in Human Spleen cells using ab5996 at 20 ug/ml.

参考文献

This product has been referenced in:
  • Sugiyama N  et al. Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1). Ann Rheum Dis 67:1461-7 (2008). WB ; Mouse . Read more (PubMed: 18094002) »
  • Takeda A  et al. WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation. Int Immunol 17:889-97 (2005). Read more (PubMed: 15908443) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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