Anti-TBC1D4 (phospho T642) 抗体 (ab59173)


  • 製品名Anti-TBC1D4 (phospho T642) antibody
    TBC1D4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TBC1D4 (phospho T642)
  • 特異性Detects endogenous levels of TBC1D4 only when phosphorylated ar theonine 642. Recognises phosphorylation at threonine 642 in human and threonine 649 in mouse.
  • アプリケーション適用あり: IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic phosphopeptide (Human) from around the phosphorylation site of threonine 642 (AHTPFS)

  • ポジティブ・コントロール
    • Human lung carcinoma tissue


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab59173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
ELISA 1/5000.


  • 機能May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
  • 組織特異性Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T cells from patients with atopic dermatitis.
  • 配列類似性Contains 2 PID domains.
    Contains 1 Rab-GAP TBC domain.
  • 翻訳後修飾Phosphorylated by AKT1; insulin-induced.
    Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation.
    Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.
  • 細胞内局在Cytoplasm. Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
  • Information by UniProt
  • 参照データベース
  • 別名
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    • TBC Tre 2 BUB2 CDC16 domain containing protein antibody
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Anti-TBC1D4 (phospho T642) antibody 画像

  • Immunohistochemical analysis of paraffin embedded human lung carcinoma tissue labelled with ab59173 at 1/50-1/100 dilution. Samples were treated with(+) or without(-) peptide.

Anti-TBC1D4 (phospho T642) antibody (ab59173) 使用論文

ab59173 has not yet been referenced specifically in any publications.

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