製品の概要

  • 製品名Anti-TAPA1 antibody [1D6]
    TAPA1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [1D6] to TAPA1
  • 特異性ab23505 recognises human CD81, a 26kD cell surface antigen also known as TAPA-1, and a member of the tetraspanin family.
  • アプリケーション適用あり: Flow Cyt, IHC-P, IP, ICC/IFmore details
    適用なし: WB
  • 種交差性
    交差種: Human, Chimpanzee
  • 免疫原

    Aggregated OCI-LY8 cells (Human).

  • 特記事項


    This antibody induces homotypic adhesion and has powerful anti proliferative effects.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab23505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-P Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.
    • 組織特異性Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
    • 関連疾患Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    • 配列類似性Belongs to the tetraspanin (TM4SF) family.
    • 翻訳後修飾Not glycosylated.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 26 kDa cell surface protein TAPA 1 antibody
      • 26 kDa cell surface protein TAPA-1 antibody
      • 26 kDa cell surface protein TAPA1 antibody
      • CD 81 antibody
      • CD81 antibody
      • CD81 antigen (target of antiproliferative antibody 1) antibody
      • CD81 antigen antibody
      • CD81 molecule antibody
      • CD81_HUMAN antibody
      • CVID6 antibody
      • S5.7 antibody
      • TAPA 1 antibody
      • TAPA1 antibody
      • Target of the antiproliferative antibody 1 antibody
      • Tetraspanin 28 antibody
      • Tetraspanin-28 antibody
      • Tetraspanin28 antibody
      • Tspan 28 antibody
      • Tspan-28 antibody
      • Tspan28 antibody
      see all

    Anti-TAPA1 antibody [1D6] (ab23505) 使用論文

    This product has been referenced in:
    • Christianson HC  et al. Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proc Natl Acad Sci U S A 110:17380-5 (2013). WB ; Human . Read more (PubMed: 24101524) »
    • Wang AL  et al. Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One 4:e4160 (2009). Flow Cyt ; Human . Read more (PubMed: 19129916) »

    See all 2 Publications for this product

    Product Wall

    Application Western blot
    Sample Human Cell lysate - whole cell (gastric)
    Loading amount 20 µg
    Specification gastric
    Gel Running Conditions Non-reduced Denaturing (4-12%)
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C
    Username

    Abcam user community

    Verified customer

    投稿 May 19 2009

    Thank you for your enquiry. I am sorry to hear that you have been having difficulties with this antibody. I am sorry but the expression of Tapa1 is outside of my area of expertese. I would appreciate it if you could explain to me why you are attempt...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"