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機能
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
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関連疾患
Defects in TAP1 are a cause of bare lymphocyte syndrome type 1 (BLS1) [MIM:604571]; also called HLA class I deficiency. BLS1 is a class I antigen deficiency that is not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract.
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配列類似性
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 1 ABC transporter domain.
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ドメイン
The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.
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細胞内局在
Endoplasmic reticulum membrane. The transmembrane segments seem to form a pore in the membrane.
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Information by UniProt
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参照データベース
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別名
- ABC 17 antibody
- ABC transporter MHC 1 antibody
- ABC17 antibody
- ABCB 2 antibody
- ABCB2 antibody
- Antigen peptide transporter 1 antibody
- APT 1 antibody
- APT1 antibody
- ATP binding cassette sub family B (MDR/TAP) member 2 antibody
- ATP binding cassette sub family B member 2 antibody
- ATP binding cassette transporter antibody
- ATP-binding cassette sub-family B member 2 antibody
- D6S114E antibody
- FLJ26666 antibody
- FLJ41500 antibody
- Peptide supply factor 1 antibody
- Peptide transporter involved in antigen processing 1 antibody
- Peptide transporter PSF 1 antibody
- Peptide transporter PSF1 antibody
- Peptide transporter TAP 1 antibody
- Peptide transporter TAP1 antibody
- PSF 1 antibody
- PSF-1 antibody
- PSF1 antibody
- Really interesting new gene 4 protein antibody
- RING 4 antibody
- RING4 antibody
- TAP 1 antibody
- TAP1 antibody
- TAP1*0102N antibody
- TAP1_HUMAN antibody
- TAP1N antibody
- Transporter 1 ATP binding cassette sub family B (MDR/TAP) antibody
- Transporter 1 ATP binding cassette sub family B antibody
- Transporter associated with antigen processing antibody
- Transporter ATP binding cassette major histocompatibility complex 1 antibody
- Y3 antibody
see all