製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Tankyrase
  • アプリケーション
    適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 972-1021 (

    VSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKE

    ) of Human Tankyrase (NP_003738).

  • ポジティブ・コントロール
    • HepG2 cell lysate

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab83978 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 142 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length.
  • 組織特異性
    Ubiquitous; highest levels in testis.
  • 配列類似性
    Contains 15 ANK repeats.
    Contains 1 PARP catalytic domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 翻訳後修飾
    Phosphorylated on serine residues by MAPK kinases upon insulin stimulation.
    ADP-ribosylated (-auto).
  • 細胞内局在
    Cytoplasm. Golgi apparatus membrane. Chromosome > centromere. Nucleus > nuclear pore complex. Chromosome > telomere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADP-ribosyltransferase diphtheria toxin-like 5 antibody
    • OTTHUMP00000115550 antibody
    • OTTHUMP00000224675 antibody
    • PARP 5a antibody
    • PARP5A antibody
    • PARPL antibody
    • pART5 antibody
    • Poly [ADP-ribose] polymerase 5A antibody
    • TANK 1 antibody
    • TANK1 antibody
    • Tankyrase 1 antibody
    • Tankyrase I antibody
    • Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase antibody
    • Tankyrase-1 antibody
    • Tankyrase1 antibody
    • TankyraseI antibody
    • TIN 1 antibody
    • TIN1 antibody
    • TINF 1 antibody
    • TINF1 antibody
    • TNKS 1 antibody
    • TNKS antibody
    • TNKS-1 antibody
    • TNKS1 antibody
    • TNKS1_HUMAN antibody
    • TRF1 interacting ankyrin related ADP ribose polymerase antibody
    • TRF1-interacting ankyrin-related ADP-ribose polymerase antibody
    see all

Anti-Tankyrase antibody 画像

  • Anti-Tankyrase antibody (ab83978) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 142 kDa
    Observed band size : 150 kDa (why is the actual band size different from the predicted?)
    Additional bands at : ~65 kDa. We are unsure as to the identity of these extra bands.
  • ab83978 at 5 µg/ml staining Tankyrase in Human small intestine tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-Tankyrase antibody (ab83978) 使用論文

ab83978 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab83978.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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