Anti-Tankyrase 2 抗体 (ab85690)

製品の概要

  • 製品名Anti-Tankyrase 2 antibody
    Tankyrase 2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Tankyrase 2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Dog
  • 免疫原

    Synthetic peptide with sequence C-

    HRRKEVSEENHNH

    , from the internal sequence of Human Tankyrase 2, NP_079511.1

  • ポジティブ・コントロール
    • Jurkat lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab85690 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 45, 125 kDa (predicted molecular weight: 127 kDa).

ターゲット情報

  • 機能Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
  • 組織特異性Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
  • 配列類似性Contains 15 ANK repeats.
    Contains 1 PARP catalytic domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 翻訳後修飾Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.
    ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
    The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
  • 細胞内局在Cytoplasm. Golgi apparatus membrane. Nucleus. Chromosome > telomere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADP-ribosyltransferase diphtheria toxin-like 6 antibody
    • ARTD6 antibody
    • PARP 5b antibody
    • PARP 5c antibody
    • PARP-5b antibody
    • PARP-5c antibody
    • PARP5B antibody
    • PARP5C antibody
    • pART6 antibody
    • Poly [ADP ribose] polymerase 5B antibody
    • Poly [ADP-ribose] polymerase 5B antibody
    • TANK2 antibody
    • Tankyrase 2 antibody
    • Tankyrase II antibody
    • Tankyrase like protein antibody
    • Tankyrase related protein antibody
    • Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody
    • Tankyrase-2 antibody
    • Tankyrase-like protein antibody
    • Tankyrase-related protein antibody
    • TNKL antibody
    • TNKS 2 antibody
    • TNKS-2 antibody
    • TNKS2 antibody
    • TNKS2_HUMAN antibody
    • TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody
    • TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody
    see all

Anti-Tankyrase 2 antibody 画像

Anti-Tankyrase 2 antibody (ab85690) 使用論文

ab85690 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Xenopus laevis Tissue lysate - whole (embryo)
Loading amount 20 µg
Specification embryo
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 20°C
Username

Ms. Sandra Gonzalez

Verified customer

投稿 Nov 27 2012

DISCOUNT CODE: 100%ABR-00000

Expiration date: 26. November 2012



I am very pleased to hear you would like to accept our offer and testab85690 in mouse and/or Xenopus. This code will give youthe value of ab85690 off a futur...

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Thank you for your reply.

I checked the immunogen sequence for ab85690 and have to confirm that most probably this antibody is not only binding to Tankyrase2 but also to Tankyrase1 since the immunogen shows a 90% homology with Tankyrase1. All...

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Thank you very much for your interest in our antibodies.

We expect cross-reactivity from antibodies when the immunogen shows a 85% homology (or higher) with another species.

The homology of theimmunogen with Xenopusis the following:...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"