製品の概要

  • 製品名Tamsulosin hydrochloride
  • 製品の詳細
    Potent, selective α1A antagonist
  • 生理活性の詳細Potent and selective α1A antagonist (pKi values are 9.97, 8.86 and 9.64 at α1A, α1B and α1D, respectively). Decreases urethral pressure in vivo with a minimal effect on mean arterial blood pressure.
  • 精製度> 99%

製品の特性

  • 体系名5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamide hydrochloride
  • 分子量444.97
  • 構造式Chemical Structure
  • 分子式C20H28N2O5S.HCl
  • CAS 番号106463-17-6
  • 保存方法Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 100 mM and in water to 10 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

  • 研究分野

    Tamsulosin hydrochloride (ab120772) 使用論文

    This product has been referenced in:
    • Ohtake A  et al. Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J Pharm Pharmacol 58:345-50 (2006). Read more (PubMed: 16536901) »
    • Taguchi K  et al. Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J Pharmacol Exp Ther 280:1-5 (1997). Read more (PubMed: 8996174) »
    • Takenaka T  et al. [Discovery and development of tamsulosin hydrochloride, a new alpha 1-adrenoceptor antagonist]. Yakugaku Zasshi 115:773-89 (1995). Read more (PubMed: 8531059) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"