製品の概要

  • 製品名Anti-TAK1 antibody
    TAK1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TAK1
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Sheep, Rabbit, Guinea pig, Hamster, Cow, Dog, Pig, Xenopus laevis, Monkey, Zebrafish
  • 免疫原

    Synthetic peptide:

    KQLEVIRSQQQKRQGTS

    conjugated to KLH by a Cysteine residue linker, corresponding to amino acids 563-579 of Mouse TAK1

  • ポジティブ・コントロール
    • Human tonsil, prostate and placenta tissues.
  • 特記事項For maximum product recovery, after thawing, centrifuge the product vial before removing cap.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 67 kDa.
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
  • 配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Association with TAB1/MAP3K7IP1 promotes autophosphorylation and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.
    Ubiquitinated, leading to proteasomal degradation (By similarity). Requires 'Lys-63'-linked polyubiquitination for autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP.
  • Information by UniProt
  • 参照データベース
  • 別名
    • M3K7_HUMAN antibody
    • MAP3K 7 antibody
    • Map3k7 antibody
    • MEKK7 antibody
    • Mitogen activated protein kinase kinase kinase 7 antibody
    • Mitogen-activated protein kinase kinase kinase 7 antibody
    • TAK1 antibody
    • TGF beta activated kinase 1 antibody
    • TGF-beta-activated kinase 1 antibody
    • TGF1a antibody
    • Transforming growth factor beta activated kinase 1 antibody
    • Transforming growth factor-beta-activated kinase 1 antibody
    see all

Anti-TAK1 antibody 画像

  • ab111096, at 10µg/ml, staining TAK1 in formalin-fixed, paraffin-embedded Human Placenta tissue by Immunohistochemistry.
  • ab111096, at 10µg/ml, staining TAK1 in formalin-fixed, paraffin-embedded Human Prostate tissue by Immunohistochemistry.
  • ab111096, at 10µg/ml, staining TAK1 in formalin-fixed, paraffin-embedded Human Tonsil tissue by Immunohistochemistry.

Anti-TAK1 antibody (ab111096) 使用論文

ab111096 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"