The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Detects a band of approximately 90 kDa (predicted molecular weight: 79 kDa).
追加情報Is unsuitable for Flow Cyt,IHC-P or IP.
機能Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
組織特異性Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
Hu MM et al. TRIM38 inhibits TNFa- and IL-1ß-triggered NF-?B activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A111:1509-14 (2014).
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