製品の概要

  • 製品名Anti-TAB2 antibody
    TAB2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to TAB2
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    C-NLDLQSQNIYHH

    with a Cysteine residue linker, corresponding to amino acids 79-90 of Human TAB2 (NP_055908.1).

  • ポジティブ・コントロール
    • Human colon tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab118485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

ターゲット情報

  • 機能Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
  • 組織特異性Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
  • 関連疾患Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).
  • 配列類似性Contains 1 CUE domain.
    Contains 1 RanBP2-type zinc finger.
  • 翻訳後修飾Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.
    Phosphorylated.
  • 細胞内局在Membrane. Cytoplasm > cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CHTD2 antibody
    • FLJ21885 antibody
    • KIAA0733 antibody
    • MAP3K7IP2 antibody
    • Mitogen activated protein kinase kinase kinase 7 interacting protein 2 antibody
    • Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody
    • OTTHUMP00000040125 antibody
    • TAB 2 antibody
    • TAB-2 antibody
    • Tab2 antibody
    • TAB2_HUMAN antibody
    • TAK1 binding protein 2 antibody
    • TAK1-binding protein 2 antibody
    • TGF beta activated kinase 1/MAP3K7 binding protein 2 antibody
    • TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody
    • TGF-beta-activated kinase 1-binding protein 2 antibody
    see all

Anti-TAB2 antibody 画像

  • ab118485 at 7.5µg/ml staining TAB2 in Formalin-fixed, Paraffin-embedded Human colon tissue by immunohistochemistry.

Anti-TAB2 antibody (ab118485) 使用論文

ab118485 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"