製品の概要

  • 製品名
    T0070907
  • 製品の詳細
    Potent, selective PPARγ antagonist
  • 生理活性の詳細
    Potent, selective PPARγ antagonist (IC50 = 1 nM). Antidiabetic actions in vivo. Inhibits rosiglitazone (ab120762). Blocks the recruitment of transcriptional cofactors to the PPARγ/RXR heterodimer.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Schaefer KL  et al. Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res 65:2251-9 (2005). Read more (PubMed: 15781638) »
  • Rockwell CE & Kaminski NE A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J Pharmacol Exp Ther 311:683-90 (2004). Read more (PubMed: 15284281) »
  • Lee G  et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem 277:19649-57 (2002). Read more (PubMed: 11877444) »

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