製品の概要

  • 製品名Anti-Syntaxin 1a (phospho S14) antibody
    Syntaxin 1a 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Syntaxin 1a (phospho S14)
  • 特異性Detects Syntaxin 1a only when phosphorylated at serine 14.
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic phosphopeptide derived from human Syntaxin 1a around the phosphorylation site of serine 14 (K-D-SP-D-D).

  • ポジティブ・コントロール
    • Brain.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab63571 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/5000.
WB 1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).

ターゲット情報

  • 機能Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
  • 組織特異性Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
  • 関連疾患Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
  • 配列類似性Belongs to the syntaxin family.
    Contains 1 t-SNARE coiled-coil homology domain.
  • 細胞内局在Secreted and Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HPC 1 antibody
    • Neuron specific antigen HPC1 antibody
    • Neuron-specific antigen HPC-1 antibody
    • OTTHUMP00000174615 antibody
    • OTTHUMP00000174616 antibody
    • OTTHUMP00000174617 antibody
    • OTTHUMP00000174618 antibody
    • P35-1 antibody
    • STX1 antibody
    • STX1A antibody
    • STX1A_HUMAN antibody
    • SYN1A antibody
    • Syntaxin 1A (brain) antibody
    • Syntaxin 1A brain antibody
    • Syntaxin-1A antibody
    see all

Anti-Syntaxin 1a (phospho S14) antibody 画像

  • All lanes : Anti-Syntaxin 1a (phospho S14) antibody (ab63571) at 1/500 dilution

    Lane 1 : Extracts from mouse brain cells (5-30µg)
    Lane 2 : Extracts from mouse brain cells (5-30µg), with immunizing phosphopeptide (5-10µg)


    Predicted band size : 33 kDa
    Observed band size : 33 kDa

Anti-Syntaxin 1a (phospho S14) antibody (ab63571) 使用論文

This product has been referenced in:
  • Gil C  et al. Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release. FEBS Lett 585:414-20 (2011). WB ; Rat . Read more (PubMed: 21187092) »
  • Rickman C & Duncan RR Munc18/Syntaxin interaction kinetics control secretory vesicle dynamics. J Biol Chem 285:3965-72 (2010). WB, ICC/IF ; Rat . Read more (PubMed: 19748891) »

See all 3 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab63571.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"