製品の概要

  • 製品名Anti-SynCAM antibody
    SynCAM 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SynCAM
  • 特異性Reacts with the C-terminal region of rat synCAM protein.
  • アプリケーション適用あり: WB, ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse
  • 免疫原

    A synthetic peptide corresponding to the C-terminal region of the rat protein.

  • ポジティブ・コントロール
    • rat brain lysate
  • 特記事項


    SynCAM is a brain-specific, immunoglobulin domain. It functions as a homophilic cell adhesion molecule at the synapse. Full-length synCAM has been shown to induce synaptic assembly. It has also been shown that synCAM, in conjunction with glutamate receptors, can sufficiently create a functional postsynaptic response.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: Serum
  • 精製度Whole antiserum
  • 一次抗体 備考SynCAM is a brain-specific, immunoglobulin domain. It functions as a homophilic cell adhesion molecule at the synapse. Full-length synCAM has been shown to induce synaptic assembly. It has also been shown that synCAM, in conjunction with glutamate receptors, can sufficiently create a functional postsynaptic response.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab3910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration. PubMed: 17548061
IHC-P Use at an assay dependent concentration. PubMed: 19643986

ターゲット情報

  • 機能Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
  • 配列類似性Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • ドメインThe cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
  • 細胞内局在Cell membrane. Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BL2 antibody
    • Cadm1 antibody
    • CADM1_HUMAN antibody
    • Cell adhesion molecule 1 antibody
    • DKFZp686F1789 antibody
    • IgSF4 antibody
    • IGSF4A antibody
    • Immunoglobulin superfamily member 4 antibody
    • MGC149785 antibody
    • MGC51880 antibody
    • NECL-2 antibody
    • NECL2 antibody
    • Nectin like 2 antibody
    • Nectin-like protein 2 antibody
    • RA175 antibody
    • SgIGSF antibody
    • Spermatogenic immunoglobulin superfamily antibody
    • ST17 antibody
    • sTSLC 1 antibody
    • Synaptic cell adhesion molecule antibody
    • SynCAM antibody
    • SynCAM1 antibody
    • TSLC-1 antibody
    • TSLC1 antibody
    • Tumor suppressor in lung cancer 1 antibody
    see all

Anti-SynCAM antibody 画像

  • All lanes : Anti-SynCAM antibody (ab3910) at 1/1000 dilution

    Lane 1 : rat brain lysate at 20 µg
    Lane 2 : rat brain crude synaptosomes at 20 µg
    Lane 3 : SynCAM transfected HEK293T cell lysate
    Lane 4 : HEK293T cell lysate

Anti-SynCAM antibody (ab3910) 使用論文

This product has been referenced in:
  • Prisco AR  et al. Tumor Necrosis Factor a Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB. Stem Cells 34:1922-33 (2016). WB ; Rat . Read more (PubMed: 26867147) »
  • Luaces JP  et al. Loss of Sertoli-germ cell adhesion determines the rapid germ cell elimination during the seasonal regression of the seminiferous epithelium of the large hairy armadillo Chaetophractus villosus. Biol Reprod 90:48 (2014). Read more (PubMed: 24451984) »

See all 10 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (Neuroblastoma cells)
Loading amount 10 µg
Specification Neuroblastoma cells
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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Abcam user community

Verified customer

投稿 Mar 16 2009

Dear Dr. Luo, Thank you for your patience. I have received a reply from the original of ab3910. The peptide sequence is proprietary information and cannot be released. As I've already mentioned in the last e-mail, the immunogen is "a syntheti...

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Thank you for your enquiry. HEK is HEK293T cells transfected with rat SynCAM. A scientist at UT Southwestern tested this antibody and said: "...the glycosylation pattern of SynCAM is different in brain and heterogously expressing cells. As you c...

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Thank you for your enquiry, the heterologous cell lysates tested were HEK cell lysates. We are currently sourcing the image for the blot of synCAM in the rat brain lysate and HEK cell lysate and as soon as we receive it we will add it to the datasheet...

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Dear Susan, I apologize for the shortage you received. I have gone ahead and set up a free of charge replacement order to be sent you soon. You will receive an e-mail confirmation once this item is ready to be shipped to you. Kind regards, Marlen

Thanks for your inquiry. The antibody was made to the C-terminus of the rat SynCam protein.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"