Anti-Synaptotagmin 1 抗体 (ab82414)
製品の概要
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製品名Anti-Synaptotagmin 1 antibody
Synaptotagmin 1 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to Synaptotagmin 1
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由来種Rabbit
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アプリケーション適用あり: WBmore details
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種交差性交差種: Rat, Xenopus laevis
非交差種: Mouse -
免疫原
Synthetic peptide derived from sequence near the amino terminus of rat Synaptotagmin 1, conjugated to KLH
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ポジティブ･コントロール
- Rat Brain and Xenopus Ovary lysates.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: 0.09% Sodium Azide
Constituents: 50% Glycerol, PBS, pH 7.2 -
Concentration information loading... -
精製度Protein A purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab82414 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/1000. Detects a band of approximately 65 kDa (predicted molecular weight: 48 kDa). |
ターゲット情報
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機能May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
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配列類似性Belongs to the synaptotagmin family.
Contains 2 C2 domains. -
ドメインThe first C2 domain mediates Ca(2+)-dependent phospholipid binding.
The second C2 domain mediates interaction with SV2A and STN2. -
細胞内局在Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane. Cytoplasm. Synaptic vesicles and chromaffin granules.
- Information by UniProt
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参照データベース
- Entrez Gene: 25716 Rat
- SwissProt: P21707 Rat
- Unigene: 216272 Rat
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別名
- DKFZp781D2042 antibody
- FLJ42519 antibody
- p65 antibody
see all
画像
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Western blot - Synaptotagmin 1 antibody (ab82414)All lanes : Anti-Synaptotagmin 1 antibody (ab82414) at 1/1000 dilution
Lane 1 : Rat Brain lysate
Lane 2 : Mouse Brain lysate
Lane 3 : Xenopus Ovary lysate
Developed using the ECL technique.
Predicted band size: 48 kDa
Observed band size: 65 kDa (why is the actual band size different from the predicted?)
プロトコール
参考文献
This product has been referenced in:
- Wang F et al. Concurrent administration of thyroxine and donepezil induces plastic changes in the prefrontal cortex of adult hypothyroid rats. Mol Med Rep 16:3233-3241 (2017). Read more (PubMed: 28713915) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"