製品の概要

  • 製品名Anti-Synaptophysin antibody [SYP02]
    Synaptophysin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SYP02] to Synaptophysin
  • 特異性This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types. This antibody is specific to a 38 kD protein.
  • アプリケーション適用あり: IHC-P, IHC-Frmore details
  • 種交差性
    交差種: Human
  • 免疫原

    BALB/C mice were injected with a synthetic peptide encoding a region near the c-terminal end of the synaptophysin protein.

  • ポジティブ・コントロール
    • Pancreas.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab6245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
IHC-Fr
  • 追加情報IHC-P: Use at an assay dependent dilution. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
    IHC-Fr: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
    • 組織特異性Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
    • 関連疾患Mental retardation, X-linked, SYP-related
    • 配列類似性Belongs to the synaptophysin/synaptobrevin family.
      Contains 1 MARVEL domain.
    • ドメインThe calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
    • 翻訳後修飾Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
    • 細胞内局在Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Major synaptic vesicle protein p38 antibody
      • MRX96 antibody
      • MRXSYP antibody
      • Syn p38 antibody
      • Synaptophysin antibody
      • Syp antibody
      • SYPH antibody
      • SYPH_HUMAN antibody
      • SypI antibody
      see all

    Anti-Synaptophysin antibody [SYP02] 画像

    • ab6245 staining human pancreas by IHC-P.

    Anti-Synaptophysin antibody [SYP02] (ab6245) 使用論文

    This product has been referenced in:
    • Fishbein TM  et al. Rejection reversibly alters enteroendocrine cell renewal in the transplanted small intestine. Am J Transplant 9:1620-8 (2009). IHC-Fr ; Human . Read more (PubMed: 19519821) »

    See 1 Publication for this product

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